Tg mice, expressing SE-positive HLA-DR4*04:01 or SE-negative HLA-DR4*04:01 human alleles31, 32 were kindly provided by Dr Chella David, at the Mayo Clinic, and are referred to as DRB1*04:01 Tg and DRB1*04:02 Tg mice, respectively. The two mouse strains have a mixed (predominantly B6) genetic background, which is ∼99% identical between them. HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 encodes the most prevalent beta subunit of HLA-DR. Several alleles of DRB1 (shared epitope alleles) are associated with an increased incidence of rheumatoid arthritis.
Jan 12, 2006 · Its main findings are that shared epitope positive HLA-DR4 alleles (in this population, mostly HLA-DRB1*0401 and HLA-DRB1*0404) are associated with extraarticular RA globally, but that neither DRB1*0401 nor DRB1*0404 is associated with any particular clinical feature, except for HLA-DRB1*0401, which is associated with Felty's syndrome. Dr Lal PathLabs offers test service for Hla Dr4 Drb104 Test for checking Disease Association. View details of cost of test, pre-test information and report availability on Dr Lal PathLabs. A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells.